Introduction: It is well known that long-term survival of Hodgkin lymphoma (HL) patients is very favourable, that is why we have to detect those high-risk patients in time who don’t respond to first-line therapy on a desirable way. Nowadays interim and restaging PET/CT is widespread, but there are some biomarkers in addition, which may help us to choose the best way of therapy and to avoid undertreatment. Patients and methods: We examined HL patients who were treated in our institute from September 2013 to March 2016. Our aim was to detect whether serum TARC (Thymus and Activation- Regulated Chemokine) protein alone or combined with PET/CT is appropriate for being a helpful biomarker in HL patients or not. Results: During this period we collected serum samples from 39 patients treated with Hodgkin lymphoma. We have got samples from 3 different times (before treatment, after 2 cycles of chemotherapy and after 6 cycles of chemotherapy) in the case of 20 patients. The mean age of the 20 patient ( 11 males and 9 females) was 42,4 years (18-75 years) at the time of the diagnosis. Three of them were in an early stage and 17 of them were in advanced stage. According to our results the activity of TARC protein measured before treatment is fit for indicating extranodal manifestations, the presence of bulky disease, and the extension of the disease, but neither it’s activity after 2 cycles of chemotherapy, nor at the end of treatment indicated refractory disease nor alone, neither combined with interim PET/CT. Conclusion: Nevertheless, Hodgkin lymphoma is one of the best curable malignancies; there are no methods except PET/CT which may help us to identify high-risk patients in time. The exact role of biomarkers needs further investigations.