Hodgkin’s Disease most commonly presents with progressive painless enlargement of peripheral lymph nodes. At diagnosis, osseous involvement is rare (<2%) and even in refractory or relapsing disease only 1/3 of the patients have any bony involvement. Systemic Hodgkin’s Disease with skeletal involvement is considered to have worse prognosis. We present a 26-year-old female, who admitted to our orthopedic department with complaints of deformity and pain in the left shoulder. Upon examination, mild local tenderness was noted with no neurological findings. Patient also had involvement of adjacent axillary and supraclavian nodes. Regarding laboratory tests, mild anemia and leukocytosis along with increased ESR and CRP were noted. Left shoulder X-Ray showed osteolytic lesion of capita arm extended to the upper third of diaphyseal humeral. Magnetic resonance imaging (MRI) showed lesions of the capita arm and diaphyseal humeral (low T1/high T2) with surrounding soft tissue mass. CT scanning revealed left axillary/supraclavian and mediastinal lymphadenopathy. Lymph node and bone mass biopsies confirmed the diagnosis of Hodgkin’ Disease (nodular sclerosis).The patient received 8 courses of ABVD with PET positivity after completion in left humerus (18FDG suv max : 3.8). Subsequently involved field radiotherapy (4000cGy) was given with no additional treatment benefit. The patient was then deferred to transplantation unit and underwent ASCT, resulting in long term complete remission (PET negative-4,5 years). Osseous involvement in systemic Hodgkin’ Disease is rare but warrants intensive treatment in order to achieve sustained remission.