Treatment of elderly patients with HL remains a difficult challenge as results and tolerance of the standard treatment with ABVD remains very inferior to adults. Bendamustine (Be), andwith Brentuximab Vedotin (BV), are active drugs, which have demonstrated a good tolerance and an high level of response in relapsing/refractory HL. To assess the safety and the efficacy of the combination of this two drugs in elderly HL , we conduct a prospective multicentric open-label stydy of Brentuximab-Vedotin (BV): 1.2 mg/kg D1 and Bendamustin (Be) 90 mg/m2/day , D1 and D2, every 3 weeks up to 6 cycles, for patients from 60 to 80 years of age, with advanced HL, stage 2B to 4,. Ten centers, 5 from Italy and 5 from France, participate to the study. A total of 60 patients are planned to be included. An evaluation by TEP-Scan will be performed after the 2nd cycle and treatment will be pursued until the 6th cycles for patients in CR according to Lugarno’s criteria. A supplementary control by TEP-scan is planned after the 4th cycle for patients in PR after 2 cycles. . Patients with progressive disease at any time or not in CR after 4 cycles will receive salvage therapy according the choice of the local investigator. A final evaluation by PET-Scan is planned for all patients after the 6th cycle. A centralized review of all TEP-Scan is planned. . The patients will be followed up for 3 years. The study is divided in 2 phases: the phase 1 with 12 patients with the main objective to evaluate the tolerability and toxicity of Be-BV and the phase 2 with 48 patients, with the primary objective to evaluate the efficacy in terms of response rate after treatment completion. The secondary objectives of the phase 2 are to evaluate the efficacy in terms of PFS, EFS and OS at 3 years, to evaluate the efficacy in terms of complete response rate after two cycles of Be-BV and to evaluate the feasibility of the treatment Currently, we have enrolled 14 patients: 9 patients have performed the first TEP-Scan evaluation after 2 cycles: 7 were in complete response and 2 in partial responses according to local evaluation. The 2 patients in PR after 2 cycles were in CR at the evaluation by PET-Scan after 4 cycles. None unexpected toxicity has been observed and the trial remains open to inclusions. The precise design of the study and updated results will be presented for the symposium. Study is supported by a grant of Millenium US/Takeda France