Background: Nowadays more than 80% of adult patients (pts) diagnosed with HL have a long-life expectancy. Pts diagnosed from late 1960’ to 2000’s are at risk of developing long-term complications from chemotherapy (CT) and radiation therapy (RT), The majority of data on iatrogenic late effects are derived from registries or self-reported interviews and only a few data on clinical outcome of suvivors followed in survivorship clinics (SC) are available. Aim: To evaluate the incidence of long-term complications among pts, in complete remission (CR) for >5 years from the end of first-line treatment (EOT), followed in the SC for adult HL survivors at INT. Methods: Medical records of 359 AHLS, who underwent a routine visit, were analyzed to evaluate data on demographic characteristics, treatment and incidence of late complications. Descriptive statistics were calculated. Results: From May 2014 to April 2016, 359 AHLS (168 males, 191 female) diagnosed at a median age of 31 (range, 17-71), underwent a routine visit at SC. Median time from EOT and last follow-up visit was 17 years (range, 5-41 years). Late complications were reported in 116 pts (32%), the majority of whom had been treated with CT+RT. After a median of 19 years (range,1-35) from EOT, 23 pts (6%) developed 29 second cancers (9 breast, 2 bladder, 2 renal, 3 prostate, 1 lung, 4 melanoma, 1 pleural mesothelioma, 1 non Hodgkin lymphoma, and 6 skin basal cell carcinoma). Cardiovascular disease (CVD) was documented in 39 pts (11%), after a median of 13.5 years (range, 3-32), and 10 pts had multiple CVDs. Among CVD, myocardial infarction occurred in 8 pts, ischemic heart disease in 4, heart failure in 4, moderate or severe valvular disease in 15 and cerebrovascular disease in 4 pts. Conventional CVD risk factors were observed in 58 pts (16%). Hypothyroidism occurred in 9% of pts. Conclusions: Results of our study confirm that a substantial proportion of survivors of adult HL develop late complications. Specific health resources should be addressed for prolonged follow-up programs, lifestyle advices as well as prompt and aggressive management of risk factors to improve health in this frail patient population.