Background: Hodgkin lymphoma (HL), frequently diagnosed at the young age, is currently treated with chemotherapy and/or radiotherapy (RT). The combination of malignancy and chemotherapy is often associated with neuro-behavioral impairment (NI), reported in up to 75% of adult survivors in various malignancies. NI involves fatigue and cognitive changes such as slowness and impairment of memory, concentration and executive functioning. NI is particularly dramatic for young adult HL survivors (YAHLS), given their age at diagnosis, long life expectancy and high curability. The current research aimed to assess the incidence and characteristics of NI in YAHLS. Methods: The study evaluated YAHLS, who completed first-line therapy (chemo±RT) and remained in complete remission (CR) for 6 months-5 years after the end of treatment. All participants completed questionnaires evaluating fatigue (MFI-20), depression (BDI-II), anxiety (HA), quality of life (QLQ-C30) and cognitive function (FACT-cog), and underwent neuropsychological evaluation. The test battery included California verbal learning test, Digit span (WAIS-III), Trail making test A+B, subtests from the Computerized Battery (CANTAB), Stroop and Raven progressive matrices tests. Processing speed, memory, and executive functions were assessed and calculated for each subject. Test and subtest results were presented in standard scores. Results: We report results of 21 YAHLS, aged 19-47 years (median 28), with mean education duration of 14.4±2.2 years. No significant depression or anxiety was observed in study participants. Severe fatigue was reported in 33% of patients. Impairment in executive functions, with scores below 1.5SD in at least 2 parameters, was observed in 33% of patients (76% below 1SD). Scores below 1.5SD in at least 2 parameters of memory were found in 19% of patients (53% below 1SD). Slow processing speed was depicted in 38% of patients (TMT-B). No correlation was found between NI and fatigue. Conclusions: NI and fatigue were observed in one third of patients. An impairment score above 1SD and especially above 1.5SD below that expected for age and education is usually regarded significant. Our results were unexpected. Given the enormous impact of these symptoms on all aspects of life, they need to be taken into consideration while assessing the efficacy of therapeutic protocols applied in YAHLS.