Introduction: Hodgkin Lymphoma (HL) is considered a potentially curable neoplasm in which most patients respond well to initial treatment. However, 10-15% of patients with localized disease and 25-30% with advanced disease experience treatment failure or relapse. In this patient group, high-dose chemotherapy followed by salvage with hematopoietic stem cells (HSCT) is considered the standard treatment. Objectives: Analysis of Overall Survival (OS) and Progression-Free Survival (PFS) in patients with HL submitted to HSCT, and identification of possible predictors of poor prognosis. Materials and Methods: A retrospective study of HL patients submitted to HSCT at two Brazilian centers was conducted. Results: A total of 106 patients were analyzed with mean follow-up time of 28.6 months (0.37 – 154.23). Regarding pre-HSCT disease status, 38 (40.9%), 45 (48.4%) and 10 (10.7%) patients had Complete Remission (CR), Partial Remission (PR) and were refractory, respectively. Response after HSCT was CR, PR and refractory in 51 (68.9%), 13 (17.6%) and 10 (13.5%) individuals, respectively. Of the 44 patients in PR before HSCT, 17 (38.6%) evolved to CR after HSCT. Three-year GS and PFS were 84.7% and 74%, respectively. Pre-HSCT influenced OS (p=0.012) and PFS (p=0.007). Conclusion: We confirmed in a Brazilian population that HSCT should be considered as a therapeutic option for patients with refractory or recurrent HL since it can promote long-term responses. Factors associated with poor prognosis were determined, allowing an individualized approach to improve response rates and minimize toxicity.