INTRODUCTION. Hodgkin’s lymphoma (HL) is a highly curable disease and 5-year survival is improving, being currently 86%. Cure rates of more than 90% for early HL and more than 70% for those with advanced HL are expected. Performing a positron emission tomography (FDG-PET), after two cycles of therapy, has proven to be a reliable tool in the prediction of patients’ outcomes, but not all patients with positive interim PET have poor outcomes. PATIENTS AND METHODS. In this single center retrospective study we collected clinical data of positive interim PET cases among all the 213 patients with a diagnosis of classic Hodgkin lymphoma admitted to our unit from 2006 to 2015. RESULTS. A positive interim PET was reported in 48/213 patients (22.5%); 24 (50%) patients were classified as having 3-4 stage disease. Median age was 29 years (14-79); 20 (42%) patients were male. The presence of B symptoms was described in 25 (53%) patients and 23 (47.9%) patients had bulky disease. ESR was high in 33 (68.8%) patients; 2 (4.2%) patients had an infiltrated bone marrow biopsy; 15 (31.3%) patients presented with extranodal disease. After the first line therapy, 17 (35%) patients experienced disease progression or a relapse. Progression Free Survival at 40 months was 62.2% (fig.1); Overall Survival was 95,7%, with a median follow-up of 38 months. 65% of our patients with a positive interim PET did not develop relapse/refractory disease, in contrast with the known prognostic value. We focused on clinical features in this population. A scleronodular histotype was present in 96% of patients, 7 (26.9%) were male. ESR was high in 20 (76.9%) patients. 24 patients (92%) had no disease at bone marrow biopsy. 6 (23.1%) patients had extranodal disease; 18 (69.2%) were younger than 45. Stages 3 or 4 were present in 11 (42.3%) patients, 14 (53.8%) presented with B symptoms, and 14 (53.8%) patients had bulky disease. We performed chi square test to compare clinical features of positive/negative PET populations, but none demonstrated a statistically relevant difference. CONCLUSION: Patients with interim PET positive in 65% of cases presented a responsive disease. Further studies could identify a series of clinical features in the interim PET positive population which may predict a better outcome. Novel approaches aim to individualise therapeutic choices, and to minimise toxicity while maximising response, above all in the era of new immunological and molecular targeting agents.